Biomedical Image Processing Group

Intravital Microscopy

An intravital microscopy is an important tool for the study of cellular and molecular mechanisms of leukocyte-endothelial interactions in the microcirculation of various tissues and in various inflammatory conditions. The analysis of the images, usually visually done, allows the counting and assessment of rolling and adherent to blood vessel walls leukocytes. However, visual analysis is a repetitive and time-consuming task, and depending on the inflammatory response degree, the measurements accuracy can be significantly affected due to the observer's visual fatigue.

Multiple Sclerosis

Multiple Sclerosis (MS) is an inflammatory demyelinating (that is, with myelin loss) disease of the Central Nervous System (CNS). It is considered an autoimmune condition in which the immune system mistakenly recognizes the myelin sheath of the CNS as an external element and attacks it, resulting in inflammation and formation of plaques (sclerosis) in multiple areas of CNS's white matter substance. The multi-contrast imaging through magnetic resonance (MR) has been successfully used in diagnosing and monitoring MS due to its excellent properties such as high resolution and superior differentiation between soft tissues.

Alzheimer's Disease

The magnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis and study of various diseases and syndromes of the central nervous system (CNS) as, for instance, multiple sclerosis and Alzheimer's disease. Besides the systematic visual analysis of MR images, the neuroradiologist often needs to measure the volume or analyze changes in the shape of specific brain structures to enable rapid and accurate diagnosis of a disease, or even to perform the follow up of a particular treatment.